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KMID : 0363220180560080489
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Korean Journal of Dermatology
2018 Volume.56 No. 8 p.489 ~ p.493
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Circumscribed Palmar Hypokeratosis Showing Bowenoid Change Secondary to Human Papilloma Virus
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Jeong Woo-Seok
Jin Woo-Jung
Moon Seung-Hyun
Hwang Bo-Hyun
Lee Sook-Kyung
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Abstract
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Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy.
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KEYWORD
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Bowenoid epidermal change, Circumscribed palmar hypokeratosis, Cryotherapy, Human papilloma virus, Ingenol mebutate
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